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The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS
Pathogen-derived nucleic acids induce potent innate immune responses(1-6). Cyclic GMP-AMP synthase (cGAS) is a dsDNA sensor that catalyzes the synthesis of a cyclic dinucleotide cGAMP, which mediates the induction of type I interferons through the STING-TBK1-IRF3 signaling axis(7-11). It was widely...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704945/ https://ncbi.nlm.nih.gov/pubmed/32911481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2749-z |
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