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Tight nuclear tethering of cGAS is essential for preventing autoreactivity
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated. A widely accepted explanation for this is the sequestration of cGAS in the cyt...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927687/ https://ncbi.nlm.nih.gov/pubmed/31808743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47491 |
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