cGAS is essential for the antitumor effect of immune checkpoint blockade

cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses. cGAS catalyzes the synthesis of cGAMP, which functions as a second messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs) and other immune modulatory molecules...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Wang, Hua, Hu, Shuiqing, Chen, Xiang, Shi, Heping, Chen, Chuo, Sun, Lijun, Chen, Zhijian J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320994/
https://ncbi.nlm.nih.gov/pubmed/28137885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621363114
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