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Preliminary Preclinical Study of Chol-DsiRNA Polyplexes Formed with PLL[30]-PEG[5K] for the RNAi-Based Therapy of Breast Cancer

RNA interference molecules have tremendous potential for cancer therapy but are limited by insufficient potency after i.v. administration. We previously found that Chol-DsiRNA Polyplexes formed between cholesterol-modified dicer-substrate siRNA (Chol-DsiRNA) and the cationic diblock copolymer PLL[30...

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Bibliografiske detaljer
Udgivet i:Nanomedicine
Main Authors: Ye, Zhen, Abdelmoaty, Mai Mohamed, Ambardekar, Vishakha V., Curran, Stephen M., Dyavar, Shetty Ravi, Arnold, Lora L., Cohen, Samuel M., Kumar, Devendra, Alnouti, Yazen, Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184584/
https://ncbi.nlm.nih.gov/pubmed/33545405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2021.102363
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