Preliminary Preclinical Study of Chol-DsiRNA Polyplexes Formed with PLL[30]-PEG[5K] for the RNAi-Based Therapy of Breast Cancer

RNA interference molecules have tremendous potential for cancer therapy but are limited by insufficient potency after i.v. administration. We previously found that Chol-DsiRNA Polyplexes formed between cholesterol-modified dicer-substrate siRNA (Chol-DsiRNA) and the cationic diblock copolymer PLL[30...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Ye, Zhen, Abdelmoaty, Mai Mohamed, Ambardekar, Vishakha V., Curran, Stephen M., Dyavar, Shetty Ravi, Arnold, Lora L., Cohen, Samuel M., Kumar, Devendra, Alnouti, Yazen, Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184584/
https://ncbi.nlm.nih.gov/pubmed/33545405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2021.102363
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