Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice

We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2(-)/(-)γc(-)/(-) (RAG-hu) humanized mouse model for HIV-1 infection. HIV-infected humanized Rag2(-)/(-)γc(-)/(-) mice (RAG-hu) were injected intravenously...

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Autors principals: Zhou, Jiehua, Neff, C Preston, Liu, Xiaoxuan, Zhang, Jane, Li, Haitang, Smith, David D, Swiderski, Piotr, Aboellail, Tawfik, Huang, Yuanyu, Du, Quan, Liang, Zicai, Peng, Ling, Akkina, Ramesh, Rossi, John J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242666/
https://ncbi.nlm.nih.gov/pubmed/21952167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.207
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