Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

One of the most formidable impediments to clinical translation of RNA interference (RNAi) is safe and effective delivery of the siRNAs to the desired target tissue at therapeutic doses. We previously described in vivo cell type-specific delivery of anti-HIV small-interfering RNAs (siRNAs) through co...

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Autors principals: Zhou, Jiehua, Neff, C Preston, Swiderski, Piotr, Li, Haitang, Smith, David D, Aboellail, Tawfik, Remling-Mulder, Leila, Akkina, Ramesh, Rossi, John J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538316/
https://ncbi.nlm.nih.gov/pubmed/23164935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.226
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