Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

One of the most formidable impediments to clinical translation of RNA interference (RNAi) is safe and effective delivery of the siRNAs to the desired target tissue at therapeutic doses. We previously described in vivo cell type-specific delivery of anti-HIV small-interfering RNAs (siRNAs) through co...

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Bibliographic Details
Main Authors: Zhou, Jiehua, Neff, C Preston, Swiderski, Piotr, Li, Haitang, Smith, David D, Aboellail, Tawfik, Remling-Mulder, Leila, Akkina, Ramesh, Rossi, John J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538316/
https://ncbi.nlm.nih.gov/pubmed/23164935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.226
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