Photoactivation of Sulfonated Polyplexes Enables Localized Gene Silencing by DsiRNA in Breast Cancer Cells

Translation potential of RNA interference nanotherapeutics remains challenging due to in vivo off-target effects and poor endosomal escape. Here, we developed novel polyplexes for controlled intracellular delivery of dicer substrate siRNA, using a light activation approach. Sulfonated polyethylenimi...

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Vydáno v:Nanomedicine
Hlavní autoři: Puri, Anu, Viard, Mathias, Zakrevsky, Paul, Zampino, Serena, Chen, Arabella, Isemann, Camryn, Alvi, Sohaib, Clogston, Jeff, Chitgupi, Upendra, Lovell, Jonathan F., Shapiro, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117728/
https://ncbi.nlm.nih.gov/pubmed/32151748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2020.102176
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