Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration

RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v. administration. We previously found that complexation with PLL(30)-PEG(5K) greatly increases the potency of 3’-cholesterol-modified siRNA [Chol-siRNA] in primary murin...

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Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Ambardekar, Vishakha V., Wakaskar, Rajesh R., Ye, Zhen, Curran, Stephen M., McGuire, Timothy R., Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927825/
https://ncbi.nlm.nih.gov/pubmed/29601972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2018.03.045
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