The efficacy of nuclease-resistant Chol-siRNA in primary breast tumors following complexation with PLL-PEG(5K)

Modifying the sense strand of nuclease-resistant siRNA with 3’-cholesterol (Chol-*siRNA) increases mRNA suppression after i.v. administration but with relatively low efficacy. We previously found evidence in vitro that suggests complexation of Chol-siRNA with PLL-PEG(5K), a block copolymer of poly-L...

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Detalhes bibliográficos
Main Authors: Ambardekar, Vishakha V., Wakaskar, Rajesh R., Sharma, Bhawna, Bowman, Joy, Vayaboury, Willy, Singh, Rakesh K., Vetro, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649532/
https://ncbi.nlm.nih.gov/pubmed/23557861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.03.021
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