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In vivo activity of nuclease-resistant siRNAs
Chemical modifications have been incorporated into short interfering RNAs (siRNAs) without reducing their ability to inhibit gene expression in mammalian cells grown in vitro. In this study, we begin to assess the potential utility of 2′-modified siRNAs in mammals. We demonstrate that siRNA modified...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright 2004 by RNA Society
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370566/ https://ncbi.nlm.nih.gov/pubmed/15100431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5239604 |
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