In vivo activity of nuclease-resistant siRNAs

Chemical modifications have been incorporated into short interfering RNAs (siRNAs) without reducing their ability to inhibit gene expression in mammalian cells grown in vitro. In this study, we begin to assess the potential utility of 2′-modified siRNAs in mammals. We demonstrate that siRNA modified...

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Bibliografiske detaljer
Main Authors: LAYZER, JULIANA M., MCCAFFREY, ANTON P., TANNER, ALICE K., HUANG, ZAN, KAY, MARK A., SULLENGER, BRUCE A.
Format: Artigo
Sprog:Inglês
Udgivet: Copyright 2004 by RNA Society 2004
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370566/
https://ncbi.nlm.nih.gov/pubmed/15100431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5239604
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