5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

5΄-Vinylphosphonate modification of siRNAs protects them from phosphatases, and improves silencing activity. Here, we show that 5΄-vinylphosphonate confers novel properties to siRNAs. Specifically, 5΄-vinylphosphonate (i) increases siRNA accumulation in tissues, (ii) extends duration of silencing in...

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Publicat a:Nucleic Acids Res
Autors principals: Haraszti, Reka A., Roux, Loic, Coles, Andrew H., Turanov, Anton A., Alterman, Julia F., Echeverria, Dimas, Godinho, Bruno M.D.C., Aronin, Neil, Khvorova, Anastasia
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570069/
https://ncbi.nlm.nih.gov/pubmed/28591791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx507
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