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5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
5΄-Vinylphosphonate modification of siRNAs protects them from phosphatases, and improves silencing activity. Here, we show that 5΄-vinylphosphonate confers novel properties to siRNAs. Specifically, 5΄-vinylphosphonate (i) increases siRNA accumulation in tissues, (ii) extends duration of silencing in...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570069/ https://ncbi.nlm.nih.gov/pubmed/28591791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx507 |
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