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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
Small interfering RNA (siRNA)-based therapies are proving to be efficient for treating liver-associated disorders. However, extra-hepatic delivery remains challenging, limiting therapeutic siRNA utility. We synthesized a panel of fifteen lipid-conjugated siRNAs and systematically evaluated the impac...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6379722/ https://ncbi.nlm.nih.gov/pubmed/30544191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1239 |
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