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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Small interfering RNA (siRNA)-based therapies are proving to be efficient for treating liver-associated disorders. However, extra-hepatic delivery remains challenging, limiting therapeutic siRNA utility. We synthesized a panel of fifteen lipid-conjugated siRNAs and systematically evaluated the impac...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379722/
https://ncbi.nlm.nih.gov/pubmed/30544191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1239
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