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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond the liver. Chemically engineering lipids may further improve siRNA delivery and efficacy, but the relationship between...
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| Опубликовано в: : | J Control Release |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546539/ https://ncbi.nlm.nih.gov/pubmed/30940496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.03.028 |
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