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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond the liver. Chemically engineering lipids may further improve siRNA delivery and efficacy, but the relationship between...
Gardado en:
| Publicado en: | J Control Release |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546539/ https://ncbi.nlm.nih.gov/pubmed/30940496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.03.028 |
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