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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond the liver. Chemically engineering lipids may further improve siRNA delivery and efficacy, but the relationship between...

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Detalles Bibliográficos
Publicado en:J Control Release
Main Authors: Biscans, Annabelle, Coles, Andrew, Echeverria, Dimas, Khvorova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546539/
https://ncbi.nlm.nih.gov/pubmed/30940496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.03.028
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