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Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2(-)/(-)γc(-)/(-) (RAG-hu) humanized mouse model for HIV-1 infection. HIV-infected humanized Rag2(-)/(-)γc(-)/(-) mice (RAG-hu) were injected intravenously...
שמור ב:
Main Authors: | , , , , , , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group
2011
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242666/ https://ncbi.nlm.nih.gov/pubmed/21952167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.207 |
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