Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence

Acute myeloid leukemia (AML) patients frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy in vitro and in vivo. This is accompanied by induction of sen...

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Dettagli Bibliografici
Pubblicato in:Cancer Discov
Autori principali: Duy, Cihangir, Li, Meng, Teater, Matt, Meydan, Cem, Garrett-Bakelman, Francine E., Lee, Tak C., Chin, Christopher R., Durmaz, Ceyda, Kawabata, Kimihito C., Dhimolea, Eugen, Mitsiades, Constantine S., Doehner, Hartmut, D’Andrea, Richard J., Becker, Michael W., Paietta, Elisabeth M., Mason, Christopher E., Carroll, Martin, Melnick, Ari M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178167/
https://ncbi.nlm.nih.gov/pubmed/33500244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1375
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