Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML

Disruption of epigenetic regulation is a hallmark of AML, but epigenetic therapy is complicated by the complexity of the epigenome. Herein, we developed a long-term primary AML ex vivo platform to determine whether targeting different epigenetic layers with 5-Azacytidine and LSD1 inhibitors would yi...

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Publicado no:Cancer Discov
Main Authors: Duy, Cihangir, Teater, Matt, Garrett-Bakelman, Francine E., Lee, Tak C., Meydan, Cem, Glass, Jacob L., Li, Meng, Hellmuth, Johannes C., Mohammad, Helai P., Smitheman, Kimberly N., Shih, Alan H., Abdel-Wahab, Omar, Tallman, Martin S., Guzman, Monica L., Muench, David, Leighton Grimes, H., Roboz, Gail J., Kruger, Ryan G., Creasy, Caretha L., Paietta, Elisabeth M., Levine, Ross L., Carroll, Martin, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606333/
https://ncbi.nlm.nih.gov/pubmed/31076479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0106
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