Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML

Epigenetic allele diversity is linked to inferior prognosis in acute myeloid leukemia (AML). However, the source of epiallele heterogeneity in AML is unknown. Herein we analyzed epiallele diversity in a genetically and clinically annotated AML cohort. Notably, AML driver mutations linked to transcri...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Li, Sheng, Chen, Xiaowen, Wang, Jiahui, Meydan, Cem, Glass, Jacob L., Shih, Alan H., Delwel, Ruud, Levine, Ross L., Mason, Christopher E., Melnick, Ari M.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710625/
https://ncbi.nlm.nih.gov/pubmed/32938585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0897
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