Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML

Epigenetic allele diversity is linked to inferior prognosis in acute myeloid leukemia (AML). However, the source of epiallele heterogeneity in AML is unknown. Herein we analyzed epiallele diversity in a genetically and clinically annotated AML cohort. Notably, AML driver mutations linked to transcri...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Li, Sheng, Chen, Xiaowen, Wang, Jiahui, Meydan, Cem, Glass, Jacob L., Shih, Alan H., Delwel, Ruud, Levine, Ross L., Mason, Christopher E., Melnick, Ari M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710625/
https://ncbi.nlm.nih.gov/pubmed/32938585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0897
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