Epigenetic identity in AML depends on disruption of non-promoter regulatory elements and is affected by antagonistic effects of mutations in epigenetic modifiers

We performed cytosine methylation sequencing on genetically diverse AML patients and found leukemic DNA methylation patterning is primarily driven by non-promoter regulatory elements and CpG shores. Enhancers displayed stronger differential methylation than promoters, consisting predominantly of hyp...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Glass, Jacob L., Hassane, Duane, Wouters, Bas J., Kunimoto, Hiroyoshi, Avellino, Roberto, Garrett-Bakelman, Francine E., Guryanova, Olga A., Bowman, Robert, Redlich, Shira, Intlekofer, Andrew M., Meydan, Cem, Qin, Tingting, Fall, Mame, Alonso, Alicia, Guzman, Monica L., Valk, Peter J.M., Thompson, Craig B., Levine, Ross, Elemento, Olivier, Delwel, Ruud, Melnick, Ari, Figueroa, Maria E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540802/
https://ncbi.nlm.nih.gov/pubmed/28408400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1032
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