AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that me...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Teater, Matt, Dominguez, Pilar M., Redmond, David, Chen, Zhengming, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Ghione, Paola, Chaudhuri, Jayanta, Gascoyne, Randy D., Aifantis, Iannis, Inghirami, Giorgio, Elemento, Olivier, Melnick, Ari, Shaknovich, Rita
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768781/
https://ncbi.nlm.nih.gov/pubmed/29335468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02595-w
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