AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that me...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Teater, Matt, Dominguez, Pilar M., Redmond, David, Chen, Zhengming, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Ghione, Paola, Chaudhuri, Jayanta, Gascoyne, Randy D., Aifantis, Iannis, Inghirami, Giorgio, Elemento, Olivier, Melnick, Ari, Shaknovich, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768781/
https://ncbi.nlm.nih.gov/pubmed/29335468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02595-w
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