EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Béguelin, Wendy, Teater, Matt, Gearhart, Micah D., Calvo Fernández, María Teresa, Goldstein, Rebecca L., Cárdenas, Mariano G., Hatzi, Katerina, Rosen, Monica, Shen, Hao, Corcoran, Connie M., Hamline, Michelle Y., Gascoyne, Randy D., Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Shaknovich, Rita, Elemento, Olivier, Bardwell, Vivian J., Melnick, Ari M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000552/
https://ncbi.nlm.nih.gov/pubmed/27505670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.07.006
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