EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require...

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Publicat a:Cancer Cell
Autors principals: Béguelin, Wendy, Teater, Matt, Gearhart, Micah D., Calvo Fernández, María Teresa, Goldstein, Rebecca L., Cárdenas, Mariano G., Hatzi, Katerina, Rosen, Monica, Shen, Hao, Corcoran, Connie M., Hamline, Michelle Y., Gascoyne, Randy D., Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Shaknovich, Rita, Elemento, Olivier, Bardwell, Vivian J., Melnick, Ari M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000552/
https://ncbi.nlm.nih.gov/pubmed/27505670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.07.006
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