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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
EZH2 is the catalytic subunit of the PRC2 Polycomb complex and mediates transcriptional repression through its histone methyltransferase activity. EZH2 is up-regulated in normal germinal center (GC) B cells and is implicated in lymphomagenesis. To explore the transcriptional programs controlled by E...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society of Hematology
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012542/ https://ncbi.nlm.nih.gov/pubmed/20736451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-280149 |
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