EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

EZH2 is the catalytic subunit of the PRC2 Polycomb complex and mediates transcriptional repression through its histone methyltransferase activity. EZH2 is up-regulated in normal germinal center (GC) B cells and is implicated in lymphomagenesis. To explore the transcriptional programs controlled by E...

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Autores principales: Velichutina, Irina, Shaknovich, Rita, Geng, Huimin, Johnson, Nathalie A., Gascoyne, Randy D., Melnick, Ari M., Elemento, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012542/
https://ncbi.nlm.nih.gov/pubmed/20736451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-280149
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