EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21(Cip1)). Deletion of Cdkn1a rescues the GC reaction in Ezh2 (−/−) mice. Using a 3D B cell follicul...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Béguelin, Wendy, Rivas, Martín A., Calvo Fernández, María T., Teater, Matt, Purwada, Alberto, Redmond, David, Shen, Hao, Challman, Matt F., Elemento, Olivier, Singh, Ankur, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638898/
https://ncbi.nlm.nih.gov/pubmed/29026085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01029-x
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