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Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells

Most antigen discovery and vaccine development aimed at driving functional B cell responses rely on mouse immunizations studies. To date, there is no 3D ex vivo immune tissues, which are capable of driving antigen-specific B cell responses to rapidly determine the humoral immunogenicity of antigens,...

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Bibliografiska uppgifter
I publikationen:Biomaterials
Huvudupphovsmän: Purwada, Alberto, Shah, Shivem B., Béguelin, Wendy, August, Avery, Melnick, Ari M., Singh, Ankur
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355359/
https://ncbi.nlm.nih.gov/pubmed/30041943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.06.034
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