Multi-tiered reorganization of the genome during B-cell affinity maturation anchored by a germinal center specific locus control region

During the humoral immune response B-cells undergo a dramatic change in phenotype to enable antibody affinity maturation in germinal centers (GCs). Using genome-wide chromosomal conformation capture (Hi-C), we found that GCB-cells undergo massive reorganization of the genomic architecture that encod...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Bunting, Karen L., Soong, T. David, Singh, Rajat, Jiang, Yanwen, Béguelin, Wendy, Poloway, David W., Swed, Brandon L., Hatzi, Katerina, Reisacher, William, Teater, Matt, Elemento, Olivier, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033726/
https://ncbi.nlm.nih.gov/pubmed/27637145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.08.012
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