The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers

To understand how the Bcl6 transcriptional repressor functions in the immune system we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of GC formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B-cells migrate to the interfollicul...

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Main Authors: Huang, Chuanxin, Gonzalez, David G., Cote, Christine M., Jiang, Yanwen, Hatzi, Katerina, Teater, Matt, Dai, Kezhi, Hla, Timothy, Haberman, Ann M., Melnick, Ari
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163070/
https://ncbi.nlm.nih.gov/pubmed/25176650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.059
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