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The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
To understand how the Bcl6 transcriptional repressor functions in the immune system we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of GC formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B-cells migrate to the interfollicul...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4163070/ https://ncbi.nlm.nih.gov/pubmed/25176650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.059 |
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