Intrinsic properties of human germinal-center B cells set antigen-affinity thresholds

Protective antibody responses to vaccination or infection depend on affinity maturation, a process by which high-affinity germinal center (GC) B cells are selected based on their ability to bind, gather and present antigen to T follicular helper (Tfh) cells. Here we show that human GC B cells have i...

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Udgivet i:Sci Immunol
Main Authors: Kwak, Kihyuck, Quizon, Nicolas, Sohn, Haewon, Saniee, Avva, Manzella-Lapeira, Javier, Holla, Prasida, Brzostowski, Joseph, Lu, Jinghua, Xie, HengYi, Xu, Chenguang, Spillane, Katelyn M., Tolar, Pavel, Pierce, Susan K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314460/
https://ncbi.nlm.nih.gov/pubmed/30504208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aau6598
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