Immunization with a T cell-dependent protein antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies

The development of vaccines for infectious diseases for which we currently have none, including HIV, will likely require the use of adjuvants that strongly promote germinal center responses and somatic hypermutation to produce broadly neutralizing antibodies. Here we compared the outcome of immuniza...

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Veröffentlicht in:Eur J Immunol
Hauptverfasser: Akkaya, Munir, Akkaya, Billur, Sheehan, Patrick W., Miozzo, Pietro, Pena, Mirna, Qi, Chen-Feng, Manzella-Lapeira, Javier, Bolland, Silvia, Pierce, Susan K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880544/
https://ncbi.nlm.nih.gov/pubmed/28762497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747113
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