Immunization with a T cell-dependent protein antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies

The development of vaccines for infectious diseases for which we currently have none, including HIV, will likely require the use of adjuvants that strongly promote germinal center responses and somatic hypermutation to produce broadly neutralizing antibodies. Here we compared the outcome of immuniza...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Eur J Immunol
Hlavní autoři: Akkaya, Munir, Akkaya, Billur, Sheehan, Patrick W., Miozzo, Pietro, Pena, Mirna, Qi, Chen-Feng, Manzella-Lapeira, Javier, Bolland, Silvia, Pierce, Susan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880544/
https://ncbi.nlm.nih.gov/pubmed/28762497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747113
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky