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MUTANT EZH2 INDUCES A PRE-MALIGNANT LYMPHOMA NICHE BY REPROGRAMMING THE IMMUNE RESPONSE

Follicular lymphomas (FL) are slow-growing, indolent tumors containing extensive follicular dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, FLs originate from highly proliferative germinal center (GC) B cells with proliferation strictly dependent on intera...

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Dades bibliogràfiques
Publicat a:Cancer Cell
Autors principals: Béguelin, Wendy, Teater, Matt, Meydan, Cem, Hoehn, Kenneth B., Phillip, Jude M., Soshnev, Alexey A., Venturutti, Leandro, Rivas, Martín A., Calvo-Fernández, María T., Gutierrez, Johana, Camarillo, Jeannie M., Takata, Katsuyoshi, Tarte, Karin, Kelleher, Neil L., Steidl, Christian, Mason, Christopher E., Elemento, Olivier, Allis, C. David, Kleinstein, Steven H., Melnick, Ari M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298875/
https://ncbi.nlm.nih.gov/pubmed/32396861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.04.004
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