MUTANT EZH2 INDUCES A PRE-MALIGNANT LYMPHOMA NICHE BY REPROGRAMMING THE IMMUNE RESPONSE

Follicular lymphomas (FL) are slow-growing, indolent tumors containing extensive follicular dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, FLs originate from highly proliferative germinal center (GC) B cells with proliferation strictly dependent on intera...

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Bibliografiske detaljer
Udgivet i:Cancer Cell
Main Authors: Béguelin, Wendy, Teater, Matt, Meydan, Cem, Hoehn, Kenneth B., Phillip, Jude M., Soshnev, Alexey A., Venturutti, Leandro, Rivas, Martín A., Calvo-Fernández, María T., Gutierrez, Johana, Camarillo, Jeannie M., Takata, Katsuyoshi, Tarte, Karin, Kelleher, Neil L., Steidl, Christian, Mason, Christopher E., Elemento, Olivier, Allis, C. David, Kleinstein, Steven H., Melnick, Ari M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298875/
https://ncbi.nlm.nih.gov/pubmed/32396861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.04.004
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