TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis

TET2 somatic mutations occur in ~10% of DLBCLs but are of unknown significance. Herein we show that TET2 is required for the humoral immune response and is a DLBCL tumor suppressor. TET2 loss of function disrupts transit of B-cells through germinal centers (GC), causing GC hyperplasia, impaired clas...

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Vydáno v:Cancer Discov
Hlavní autoři: Dominguez, Pilar M., Ghamlouch, Hussein, Rosikiewicz, Wojciech, Kumar, Parveen, Béguelin, Wendy, Fontán, Lorena, Rivas, Martín A., Pawlikowska, Patrycja, Armand, Marine, Mouly, Enguerran, Torres-Martin, Miguel, Doane, Ashley S., Calvo Fernandez, María T., Durant, Matt, Della-Valle, Veronique, Teater, Matt, Cimmino, Luisa, Droin, Nathalie, Tadros, Saber, Motanagh, Samaneh, Shih, Alan H., Rubin, Mark A., Tam, Wayne, Aifantis, Iannis, Levine, Ross L., Elemento, Olivier, Inghirami, Giorgio, Green, Michael R., Figueroa, Maria E., Bernard, Olivier A., Aoufouchi, Said, Li, Sheng, Shaknovich, Rita, Melnick, Ari M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279514/
https://ncbi.nlm.nih.gov/pubmed/30274972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0657
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