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TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis
The TET2 DNA hydroxymethyltransferase is frequently disrupted by somatic mutations in diffuse large B cell lymphomas (DLBCLs), a tumor that originates from germinal center (GC) B cells. Here, we show that TET2 deficiency leads to DNA hypermethylation of regulatory elements in GC B cells, associated...
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| Wydane w: | Sci Adv |
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| Główni autorzy: | , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Association for the Advancement of Science
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7299612/ https://ncbi.nlm.nih.gov/pubmed/32596441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay5872 |
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