TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

The TET2 DNA hydroxymethyltransferase is frequently disrupted by somatic mutations in diffuse large B cell lymphomas (DLBCLs), a tumor that originates from germinal center (GC) B cells. Here, we show that TET2 deficiency leads to DNA hypermethylation of regulatory elements in GC B cells, associated...

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Pubblicato in:Sci Adv
Autori principali: Rosikiewicz, Wojciech, Chen, Xiaowen, Dominguez, Pilar M., Ghamlouch, Hussein, Aoufouchi, Said, Bernard, Olivier A., Melnick, Ari, Li, Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299612/
https://ncbi.nlm.nih.gov/pubmed/32596441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay5872
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