AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that me...

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Publicado en:Nat Commun
Autores principales: Teater, Matt, Dominguez, Pilar M., Redmond, David, Chen, Zhengming, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Ghione, Paola, Chaudhuri, Jayanta, Gascoyne, Randy D., Aifantis, Iannis, Inghirami, Giorgio, Elemento, Olivier, Melnick, Ari, Shaknovich, Rita
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768781/
https://ncbi.nlm.nih.gov/pubmed/29335468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02595-w
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