AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that me...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Teater, Matt, Dominguez, Pilar M., Redmond, David, Chen, Zhengming, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Ghione, Paola, Chaudhuri, Jayanta, Gascoyne, Randy D., Aifantis, Iannis, Inghirami, Giorgio, Elemento, Olivier, Melnick, Ari, Shaknovich, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768781/
https://ncbi.nlm.nih.gov/pubmed/29335468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02595-w
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