Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence

Acute myeloid leukemia (AML) patients frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy in vitro and in vivo. This is accompanied by induction of sen...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Duy, Cihangir, Li, Meng, Teater, Matt, Meydan, Cem, Garrett-Bakelman, Francine E., Lee, Tak C., Chin, Christopher R., Durmaz, Ceyda, Kawabata, Kimihito C., Dhimolea, Eugen, Mitsiades, Constantine S., Doehner, Hartmut, D’Andrea, Richard J., Becker, Michael W., Paietta, Elisabeth M., Mason, Christopher E., Carroll, Martin, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178167/
https://ncbi.nlm.nih.gov/pubmed/33500244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1375
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