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Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo

Cytotoxic T cells (CTLs) can eliminate tumor cells through the delivery of lethal hits, but the actual efficiency of this process in the tumor microenvironment is unclear. Here, we visualized the capacity of single CTLs to attack tumor cells in vitro and in vivo using genetically encoded reporters t...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Khazen, Roxana, Cazaux, Marine, Lemaître, Fabrice, Corre, Beatrice, Garcia, Zacarias, Bousso, Philippe
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167356/
https://ncbi.nlm.nih.gov/pubmed/33855732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106658
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