Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

Anti-CD20 antibody (mAb) represents an effective strategy for the treatment of B cell malignancies, possibly involving complement activity, antibody-dependent cellular cytotoxicity and phagocytosis (ADP). While ADP by Kupffer cells deplete circulating tumors, mechanisms targeting non-circulating tum...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Grandjean, Capucine L., Garcia, Zacarias, Lemaître, Fabrice, Bréart, Béatrice, Bousso, Philippe
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895428/
https://ncbi.nlm.nih.gov/pubmed/33608271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6167
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