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Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo

Cytotoxic T cells (CTLs) can eliminate tumor cells through the delivery of lethal hits, but the actual efficiency of this process in the tumor microenvironment is unclear. Here, we visualized the capacity of single CTLs to attack tumor cells in vitro and in vivo using genetically encoded reporters t...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Khazen, Roxana, Cazaux, Marine, Lemaître, Fabrice, Corre, Beatrice, Garcia, Zacarias, Bousso, Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167356/
https://ncbi.nlm.nih.gov/pubmed/33855732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106658
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