Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma–be...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Cazaux, Marine, Grandjean, Capucine L., Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J., Milo, Idan, Postat, Jérémy, Beltman, Joost B., Cheadle, Eleanor J., Bousso, Philippe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504219/
https://ncbi.nlm.nih.gov/pubmed/30936262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182375
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