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Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment
The cytokine IFN-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. While IFN-γ production is targeted at the immunological synapse, its spatiotemporal activity within the tumor remains elusive. Here, we report that while IFN-...
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| Publicado no: | Nat Cancer |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7115926/ https://ncbi.nlm.nih.gov/pubmed/32803171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0038-2 |
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