Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

The cytokine IFN-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. While IFN-γ production is targeted at the immunological synapse, its spatiotemporal activity within the tumor remains elusive. Here, we report that while IFN-...

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Publicado en:Nat Cancer
Autores principales: Thibaut, Ronan, Bost, Pierre, Milo, Idan, Cazaux, Marine, Lemaître, Fabrice, Garcia, Zacarias, Amit, Ido, Breart, Béatrice, Cornuot, Clémence, Schwikowski, Benno, Bousso, Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115926/
https://ncbi.nlm.nih.gov/pubmed/32803171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0038-2
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