Targeting eIF4A Dependent Translation of KRAS Signaling Molecules

Pancreatic adenocarcinoma (PDAC) epitomizes a deadly cancer driven by abnormal KRAS signalling. Here we show that the eIF4A RNA helicase is required for translation of key KRAS signaling molecules and that pharmacological inhibition of eIF4A has single-agent activity against murine and human PDAC mo...

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Publicat a:Cancer Res
Autors principals: Singh, Kamini, Lin, Jianan, Lecomte, Nicolas, Mohan, Prathibha, Gokce, Askan, Sanghvi, Viraj R., Jiang, Man, Grbovic-Huezo, Olivera, Burčul, Antonija, Stark, Stefan G., Romesser, Paul B., Chang, Qing, Melchor, Jerry P., Beyer, Rachel K., Duggan, Mark, Fukase, Yoshiyuki, Yang, Guangli, Ouerfelli, Ouathek, Viale, Agnes, de Stanchina, Elisa, Stamford, Andrew W., Meinke, Peter T., Rätsch, Gunnar, Leach, Steven D., Ouyang, Zhengqing, Wendel, Hans-Guido
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137674/
https://ncbi.nlm.nih.gov/pubmed/33632898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2929
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