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Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin

Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration. Upon completion of the first total synthesis of migrastatin, a number of structurally simplified analogs were prepared. Following extensive in vitro screening, a new g...

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Autors principals: Lecomte, Nicolas, Njardarson, Jon T., Nagorny, Pavel, Yang, Guangli, Downey, Robert, Ouerfelli, Ouathek, Moore, Malcolm A. S., Danishefsky, Samuel J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174672/
https://ncbi.nlm.nih.gov/pubmed/21808037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015247108
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