Targeting eIF4A Dependent Translation of KRAS Signaling Molecules

Pancreatic adenocarcinoma (PDAC) epitomizes a deadly cancer driven by abnormal KRAS signalling. Here we show that the eIF4A RNA helicase is required for translation of key KRAS signaling molecules and that pharmacological inhibition of eIF4A has single-agent activity against murine and human PDAC mo...

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Publicado no:Cancer Res
Main Authors: Singh, Kamini, Lin, Jianan, Lecomte, Nicolas, Mohan, Prathibha, Gokce, Askan, Sanghvi, Viraj R., Jiang, Man, Grbovic-Huezo, Olivera, Burčul, Antonija, Stark, Stefan G., Romesser, Paul B., Chang, Qing, Melchor, Jerry P., Beyer, Rachel K., Duggan, Mark, Fukase, Yoshiyuki, Yang, Guangli, Ouerfelli, Ouathek, Viale, Agnes, de Stanchina, Elisa, Stamford, Andrew W., Meinke, Peter T., Rätsch, Gunnar, Leach, Steven D., Ouyang, Zhengqing, Wendel, Hans-Guido
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137674/
https://ncbi.nlm.nih.gov/pubmed/33632898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2929
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