Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at an advanced stage, which limits surgical options and portends a dismal prognosis. Current oncologic PDAC therapies confer marginal benefit and, thus, a significant unmet clinical need exists for new therapeutic strategies. To identify...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Grbovic-Huezo, Olivera, Pitter, Kenneth L., Lecomte, Nicolas, Saglimbeni, Joseph, Askan, Gokce, Holm, Matilda, Melchor, Jerry P., Chandwani, Rohit, Joshi, Suhasini, Haglund, Caj, Iacobuzio-Donahue, Christine A., Chiosis, Gabriela, Tammela, Tuomas, Leach, Steven D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720119/
https://ncbi.nlm.nih.gov/pubmed/33199632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920240117
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