PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk

Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreati...

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Pubblicato in:Cancer Res
Autori principali: Sinha, Smrita, Fu, Ya-Yuan, Grimont, Adrien, Ketcham, Maren, Lafaro, Kelly, Saglimbeni, Joseph A., Askan, Gokce, Bailey, Jennifer M., Melchor, Jerry P., Zhong, Yi, Joo, Min Geol, Grbovic-Huezo, Olivera, Yang, In-Hong, Basturk, Olca, Baker, Lindsey, Park, Young, Kurtz, Robert C., Tuveson, David, Leach, Steven D., Pasricha, Pankaj J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471615/
https://ncbi.nlm.nih.gov/pubmed/28386018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0899-T
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