PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk

Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreati...

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Udgivet i:Cancer Res
Main Authors: Sinha, Smrita, Fu, Ya-Yuan, Grimont, Adrien, Ketcham, Maren, Lafaro, Kelly, Saglimbeni, Joseph A., Askan, Gokce, Bailey, Jennifer M., Melchor, Jerry P., Zhong, Yi, Joo, Min Geol, Grbovic-Huezo, Olivera, Yang, In-Hong, Basturk, Olca, Baker, Lindsey, Park, Young, Kurtz, Robert C., Tuveson, David, Leach, Steven D., Pasricha, Pankaj J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471615/
https://ncbi.nlm.nih.gov/pubmed/28386018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0899-T
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